Utilité d’une supplémentation de vitamine D dans un essai clinique japonais destiné à tester l’association entre vitamine D et occurrence d’une grippe.
La conclusion c’est que 10% des enfants supplémentés en vitamine D avaient souffert de la grippe par rapport à 18%. Par ailleurs, 2 enfants avec un historique d’asthme ont eu une crise durant l’occurrence de la grippe, par rapport à 12 dans le groupe placebo.
https://www.ncbi.nlm.nih.gov/pubmed/20219962/
Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren.
Urashima M1, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H.Author information1Division of Molecular Epidemiology, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan. urashima@jikei.ac.jpAbstractBACKGROUND:To our knowledge, no rigorously designed clinical trials have evaluated the relation between vitamin D and physician-diagnosed seasonal influenza.
OBJECTIVE:
We investigated the effect of vitamin D supplements on the incidence of seasonal influenza A in schoolchildren.
DESIGN:
From December 2008 through March 2009, we conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D(3) supplements (1200 IU/d) with placebo in schoolchildren. The primary outcome was the incidence of influenza A, diagnosed with influenza antigen testing with a nasopharyngeal swab specimen.
RESULTS:
Influenza A occurred in 18 of 167 (10.8%) children in the vitamin D(3) group compared with 31 of 167 (18.6%) children in the placebo group [relative risk (RR), 0.58; 95% CI: 0.34, 0.99; P = 0.04]. The reduction in influenza A was more prominent in children who had not been taking other vitamin D supplements (RR: 0.36; 95% CI: 0.17, 0.79; P = 0.006) and who started nursery school after age 3 y (RR: 0.36; 95% CI: 0.17, 0.78; P = 0.005). In children with a previous diagnosis of asthma, asthma attacks as a secondary outcome occurred in 2 children receiving vitamin D(3) compared with 12 children receiving placebo (RR: 0.17; 95% CI: 0.04, 0.73; P = 0.006).
CONCLUSION:
This study suggests that vitamin D(3) supplementation during the winter may reduce the incidence of influenza A, especially in specific subgroups of schoolchildren. This trial was registered at https://center.umin.ac.jp as UMIN000001373.